Sustanon 250 Cycle: The Ultimate Guide

Dr George TouliatosDisclaimer: The following article is for educational purposes only and does not promote the use of illegal steroids. If you have any questions or concerns, Dr. Touliatos is currently available for consultation.


Sustanon 250, produced by Organon, is a popular anabolic that contains a distinctive blend of four testosterone esters, delivering a unique, staggered release of the hormone post-injection.

In this guide, we take a closer look at the pros and cons of this renowned testosterone mix, plus Sustanon 250 cycle information and stacks used by bodybuilders today.

Firstly, when you inject Sustanon 250 (often abbreviated to “Sust”), the anabolic hormone you are administering is testosterone.

Sustanon 250 is a blend of different testosterone esters; however, it is still essentially testosterone, like cypionate or enanthate.

Therefore, in terms of muscle gains, it does not matter what form of testosterone you use, as it is the same compound and thus will produce an identical end result.

As with any testosterone product, we have found Sustanon 250 to be an excellent steroid for increasing muscle mass, strength, and power (1).

The main difference between Sustanon 250 and other testosterone products is that Sustanon 250 has 4 esters instead of 1.

Disclosure: We do not accept any form of advertising on Inside Bodybuilding. We monetize our practice via doctor consultations and carefully chosen pharmaceutical recommendations, which have given our patients excellent results.

Best Sustanon 250 Source

sustanon 250

If you suffer from hypogonadism and require sustanon 250 for medicinal purposes, we recommend Prestige Pharmaceuticals due to their product efficacy and fast worldwide shipping (2–6 days).

Testosterone is legal to purchase in some countries and not in others; thus, it is the responsibility of users to act within the confines of their native law.

Inside Bodybuilding does not condone the use of AAS via illegal means or for cosmetic use.

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What is an ester, and why does it matter?

testosterone structure

An ester is a carbon chain attached to the testosterone molecule that slows the release of the hormone in the body.

At one end of the spectrum is pure testosterone with no esters attached, such as testosterone suspension. Once injected, we see the compound quickly released in the body. This causes a fairly rapid spike in serum testosterone, which remains elevated for only a short period of time.

On the other end of the spectrum, we have the likes of testosterone enanthate and cypionate, which contain long ester chains, resulting in a slower release of testosterone after injection (2); and subsequently, an elevated level of the hormone remains for a couple of weeks in our experience.

In between these two are various other esters. The propionate ester is a popular choice for users who want a fairly quick elevation of the steroid that lasts only several days.

For bodybuilders and athletes, an important requirement is the need to keep a relatively stable concentration of testosterone in the bloodstream. We find that by doing this, it produces the desired anabolic benefits while avoiding the undesirable side effects that stem from volatile peaks and dips.

With this in mind, shorter esters require regular injections (daily or every other day), whereas longer esters, such as enanthate, typically only require injections once or twice a week.

This is where Sustanon 250 is unique, with it containing quick-releasing propionate and phenylpropionate esters and slower-releasing decanoate and isocaproate esters, resulting in a blend that effectively produces a quick yet enduring release of testosterone.

How Often Do You Need to Inject Sustanon 250?

Like Testosterone Enanthate, Sustanon 250 can be injected once or twice per week.

It is always advisable to opt for the original Organon product (pharmaceutical grade) and avoid underground versions that try to mimic the Sustanon blend.

Sustanon 250 is usually fairly easy and inexpensive to source.

Each ampule contains 250mg of testosterone, comprised as follows:

  • 100mg testosterone decanoate
  • 60mg testosterone isocaproate
  • 60mg testosterone phenylpropionate
  • 30mg of testosterone propionate

What Results Can I Expect?

Being the primary, naturally occurring male hormone, testosterone is the number one compound in the world of anabolic-androgenic steroids.

We have found testosterone to be generally well-tolerated based on our testing. Thus, we consider it to be the best choice for someone’s first cycle, as well as providing the perfect base compound for experienced bodybuilders stacking several compounds together.

While results vary from person to person and depend on various other variables, users can expect testosterone to cause significant increases in muscle size and strength.

Our patients, who are fairly new to anabolics, typically report Sustanon 250 cycles producing 20+ lbs of weight gain over the course of a cycle, with roughly two-thirds of such weight being kept (once a cycle ceases and water retention normalizes).

Enanthate and cypionate are the most popular testosterone esters, as they do not need to be injected frequently. However, we find they take a while to kick in and produce results. However, with Sustanon 250, users can experience fast results in the early stages of a cycle due to the presence of propionate and phenylpropionate esters (yet they can be injected at the same frequency as enanthate or cypionate).

For those who have already cycled other testosterone esters, there is little difference between swapping those esters for Sustanon 250 in terms of dosage guidelines and stacking options.

Sensitive individuals that are prone to side effects with testosterone are likely to experience the same outcome with Sustanon 250.

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Sustanon 250 Cycles and Stacks

Testosterone is a versatile hormone suitable for both bulking and cutting cycles due to its simultaneous anabolic and fat-burning effects.

However, our patients typically use Sustanon 250 in bulking cycles, where maximum muscle gain is the goal. We have seen great results achieved from running Sustanon on its own, yet many choose to stack it with other steroids that are also suited for adding mass, such as Anadrol.

Sustanon 250 is also effective on its own during cutting cycles, promoting muscle retention and decreasing fat mass.

Many bodybuilders are afraid of losing muscle tissue when cutting due to the catabolic environment that occurs with a calorie deficit; however, testosterone can alleviate such worries of diminished muscle hypertrophy.

We have seen a moderate dose of Sustanon 250 (350 mg/week) often preserve lean tissue during a cut, especially when stacked with other compounds that aid fat loss and muscle hardening, such as:

  1. Anavar
  2. Trenbolone

Additionally, when using Sustanon for a cutting cycle, the use of an anti-aromatase in low doses can prove particularly useful for preventing water retention and gynecomastia, in our experience.

For informational purposes, here are some common Sustanon 250 cycles and stacks utilized by bodybuilders today:

Sustanon 250 Beginner Cycle

beginner sustanon 250 cycle

Note: Large gains in hypertrophy (size) and strength can be experienced at lower dosages among beginners, due to the muscles being particularly receptive to exogenous testosterone. Thus, beginners should avoid utilizing high dosages, allowing more potential for growth in future cycles where higher dosages may be incorporated.

In our testing, a PCT should begin 4 weeks following the final dosage, with decanoate’s half-life being 15 days and thus taking considerably longer to exit the body.

Such PCT timing can also be applied to the steroid cycles below.

Sustanon 250 Intermediate Cycle

intermediate sustanon 250 cycle

This Sustanon 250 cycle will continue adding mass to users who have already taken a cautiously dosed testosterone cycle previously.

However, we have found that running higher dosages will produce more pronounced side effects, which we will detail in the side effects section of this guide (further down).

Sustanon 250 and Anavar Cycle (Cutting)

Anavar is an oral steroid predominantly used for cutting to enhance fat-burning and muscle gains.

Thus, users will burn more subcutaneous fat with this cycle and experience additional lean mass compared to running Sustanon 250 by itself.

Anavar does not aromatize, so we see it producing a dry and ripped appearance in our patients, who are already relatively low in body fat.

Anavar is a mild steroid; thus the following will only rise moderately based on our lipid profiles and LFTs:

  1. Cholesterol
  2. Blood pressure
  3. ALT/AST liver enzymes

sustanon anavar cycle

Note: Users wanting to avoid water retention or bloating on this cutting cycle can take anastrozole. We find that taking 0.5mg every other day successfully prevents estrogen levels from rising.

Sustanon 250 and Deca Durabolin Cycle

deca durabolin sustanon 250
This is a powerful bulking cycle, yet one of the mildest stacks in terms of side effects that we see.

This cycle may be utilized after running several testosterone cycles, promoting further muscle growth.

sustanon 250 deca cycle

Deca Durabolin has long esters and thus is a slow-acting steroid, hence the lengthy 10-week cycle.

Deca Durabolin is typically injected once per week.

Both testosterone and Deca Durabolin remain FDA-approved steroids in the world of medicine today, showcasing their safety when used under medical supervision and in therapeutic dosages.

However, we know that bodybuilding dosages often exceed these.

Sustanon 250 and Trenbolone Cycle

Sustanon 250 and trenbolone are a potent combination, used for either bulking or cutting purposes.

This duo will cause exceptional muscle gains while simultaneously stimulating rapid fat loss due to high levels of androgens (causing a direct fat-burning effect in adipose tissue).

These two compounds are perhaps the best steroids for increasing lean mass when run simultaneously.

sustanon 250 trenbolone cycle

However, we find this cycle only suitable for advanced steroid users due to trenbolone’s toxic nature in regard to cardiovascular health (3).

If this cycle is utilized for cutting purposes, an anti-estrogen such as anastrozole may be used to prevent water retention.

However, doing so can exacerbate high blood pressure due to it inhibiting the aromatase enzyme and thus worsening cholesterol ratios. Thus, we do not have our patients take anastrozole when their blood pressure is already high.

Sustanon 250 / Anadrol / Trenbolone Cycle

Note: This cycle is only typically performed by experienced steroid users.

This is by far the most potent bulking cycle a bodybuilder can take, causing unrivaled increases in mass in our experience.

We have seen users take steroids for decades and still make impressive gains from this cycle, due to the sheer power of this trio.

testosterone anadrol tren cycle

This cycle should only be taken on rare occasions, with its devastating effects on the heart and liver.

The liver strain will be significant (albeit most likely tolerable) due to anadrol being the only hepatotoxic compound present.

However, cholesterol levels will change drastically, almost certainly causing some level of hypertension. The risk of developing arteriosclerosis and heart disease is high with this cycle, so if users have a history of such in their family, it may be wise to avoid such an extreme cycle.

Testosterone suppression will almost certainly shut down this trio. We have found incorporating an aggressive PCT, including the following medications, to be effective in restoring the HPT axis (4,5):

  1. Clomid
  2. Nolvadex
  3. HCG

Although the above cycles are the most popular protocols, testosterone can also be successfully stacked with other anabolic steroids, such as:

Sustanon 250 Results: Before and After

testosterone cycle before after

This before and after picture demonstrates the typical results we see in users after their first testosterone/Sustanon 250 cycle.

Testosterone’s fat-burning effects are often underappreciated, with them being arguably as powerful as testosterone’s anabolic properties.

Thus, weight gain may not be the best method for tracking results on testosterone, with before and after pictures being more telling.

We often see users lose weight post-cycle, signifying a decrease in estrogen and thus a loss in extracellular fluid.

However, the majority of lean muscle tissue will be retained after a cycle finishes, should users continue lifting weights regularly.

We see strength gains of 50+lbs being common (on main compound lifts) when taking testosterone for the first time.

Sustanon 250 Side Effects

As with other testosterone products, Sustanon 250 can produce several undesirable side effects.

Firstly, we see androgenic-related side effects being relatively common, including:

  1. Oily skin
  2. Acne
  3. Accelerated baldness
  4. Increased aggressiveness

As with all steroids, tolerance differs from person to person. It is only possible to gauge such sensitivity once a cycle is embarked upon.

That said, if users are particularly prone to acne breakouts or currently suffer from male pattern baldness, testosterone and other androgenic steroids can be expected to worsen such conditions, in our experience.

Further unwanted side effects can occur due to heightened estrogen levels rising during a Sustanon 250 cycle due to aromatization (the conversion of testosterone into estrogen).

Heightened estrogen levels can cause increased water retention and gynecomastia—the formation of breast tissue.

We find the initial stages of gynecomastia typically involve itchy or sore nipples, developing into a notable mass of tissue behind the nipple. If left unchecked, such tissue can continue to expand and is only then rectifiable with surgery.

Thankfully, most of our patients find testosterone tolerable and do not suffer from gynecomastia. For those that do, such estrogen-related side effects can usually be controlled with either an anti-estrogen or AI (aromatase inhibitor).

Anti-estrogen products (such as Nolvadex and Clomid) actively compete with estrogen at a receptor level, reducing the female hormone’s effects.

Both Nolvadex and Clomid are inexpensive and easy to source; it is always advisable to have an ample supply on hand during and after a cycle. They are also the primary drugs we use during post-cycle therapy (PCT) to kickstart endogenous testosterone production.

It is also possible to reduce estrogen levels by taking an anti-aromatase drug, such as:

  • Letrozole
  • Anastrozole

These drugs reduce the conversion of testosterone into estrogen and are typically taken during a cycle by those prone to estrogenic side effects.

Testosterone will also suppress endogenous testosterone levels, causing potential testicular atrophy (shrinkage). Thus, at the end of any cycle, always ensure to run a proper post-cycle therapy that aids in the recovery of natural hormone production. We have found hCG to be specifically effective in treating testicular atrophy.

Sustanon 250 does not cause any hepatic (liver) implications due to it being an injectable steroid.

Sustanon 250 and other testosterone esters will raise LDL cholesterol levels; however, this effect is acute compared to other AAS in our testing.

Testosterone is one of the least destructive steroids from a cardiovascular standpoint; however, precautions should still be taken, including fish oil supplementation (4 g/day), regular cardio, and frequent checkups with your doctor to monitor blood lipids.

Sustanon 250 Review

A member of our private Facebook group posted this Sustanon 250 review.

I started cycling Sustanon 250, and I’m on week 4 now. This stuff is amazing. I’m taking 1 ml a week, and I feel great, with no crashes and amazing energy. I did get some small acne in week one on my shoulders, so I lowered the dose to 0.9 ml, and it started going away. I haven’t felt this great on gear since my first cycle of Test Cypionate 3 years ago.

Co Authors :

(1) Skinner, J. W., Otzel, D. M., Bowser, A., Nargi, D., Agarwal, S., Peterson, M. D., Zou, B., Borst, S. E., & Yarrow, J. F. (2018, March 15). Muscular responses to testosterone replacement vary by administration route: a systematic review and meta‐analysis. Journal of Cachexia, Sarcopenia and Muscle.

(2) National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 9416, Testosterone Enanthate.

(3) Shahsavari Nia, Kavous et al. “A Young Man with Myocardial Infarction due to Trenbolone Acetate; a Case Report.” Emergency (Tehran, Iran) vol. 2,1 (2014): 43-5.

(4) Habous, M., Giona, S., Tealab, A., Aziz, M., Williamson, B., Nassar, M., Abdelrahman, Z., Remeah, A., Abdelkader, M., Binsaleh, S., & Muir, G. (2018). Clomiphene citrate and human chorionic gonadotropin are both effective in restoring testosterone in hypogonadism: a short-course randomized studyBJU International122(5), 889–897.

(5) Rambhatla, Amarnath et al. “The Role of Estrogen Modulators in Male Hypogonadism and Infertility.” Reviews in urology vol. 18,2 (2016): 66-72.