Sustanon 250 Cycle: The Ultimate Guide

Dr George TouliatosDisclaimer: The following article is for educational purposes only and NOT to promote the use of illegal steroids. If you have any questions or concerns, Dr. Touliatos is currently available for consultations.

Sustanon 250, produced by Organon, is a popular anabolic that contains a distinctive blend of four testosterone esters; delivering a unique, staggered release of the hormone post-injection.

In this guide, we take a closer look at the pros and cons of this renowned testosterone mix, plus Sustanon 250 cycle information and stacks used by bodybuilders today.

Firstly, when you inject Sustanon 250 (often abbreviated to “Sust”), the anabolic hormone you are administering is testosterone.

Sustanon 250 is a blend of different testosterone esters; however, it is still essentially testosterone; like cypionate or enanthate.

Therefore, in terms of muscle gains, it does not matter what form of testosterone you use, as it is the same compound and thus will produce an identical end result.

Thus, as with any testosterone product, Sustanon 250 is an excellent steroid for increasing muscle mass, strength and power.

The main difference between Sustanon 250 and other testosterone products, is that it has 4 esters, instead of 1.

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What is an “Ester” and Why Does it Matter?

testosterone structure

An ester is a carbon chain attached to the testosterone molecule that slows the release of the hormone in the body.

At one end of the spectrum is pure testosterone with no esters attached, such as testosterone suspension.

Once injected, the hormone is quickly released in the body and causes a fairly rapid spike in serum testosterone, which remains elevated for only a short period of time.

On the other end of the spectrum, we have the likes of testosterone enanthate and cypionate which contain long ester chains, resulting in a slower release of testosterone after injection; and subsequently, an elevated level of the hormone remains for a couple of weeks.

In between these two are various other esters. The propionate ester is a popular choice for users who want a fairly quick elevation of the steroid, that lasts only several days.

For bodybuilders and athletes, an important requirement is the need to keep a relatively stable concentration of testosterone in the bloodstream. Doing so produces the desired anabolic benefits, whilst avoiding the undesirable side effects that stem from volatile hormone levels (which excessively peak and dip).

With this in mind, shorter esters require regular injections (daily or every other day), whereas longer esters, such as enanthate, typically only require injections once or twice a week.

This is where sustanon 250 is unique, with it containing quick releasing propionate and phenylpropionate esters, and slower releasing decanoate and isocaproate esters – resulting in a blend that effectively produces a quick, yet enduring release of testosterone.

How Often Do You Need to Inject Sustanon 250?

Like Testosterone enanthate, Sustanon 250 can be injected once or twice per week.

It is always advisable to opt for the original Organon product (pharmaceutical grade) and avoid underground versions that try to mimic the Sustanon blend.

Sustanon 250 is usually fairly easy and inexpensive to source.

Each ampule contains 250mg of testosterone, comprised as follows:

  • 100mg testosterone decanoate
  • 60mg testosterone isocaproate
  • 60mg testosterone phenylpropionate
  • 30mg of testosterone propionate.

What Results Can I Expect?

Being the primary, naturally occurring male hormone; testosterone is the number one compound in the world of anabolic-androgenic steroids.

It is generally well-tolerated and widely considered the best choice for someone’s first cycle, as well as providing the perfect base compound for experienced bodybuilders when stacking several hormones together.

While results vary from person to person and depend on various other variables, users can expect testosterone to cause significant increases in muscle size and strength.

Those who are fairly new to anabolics and want to gain muscle mass, typically report Sustanon 250 cycles producing 20+lbs of weight gain over the course of a cycle; with roughly two-thirds of such weight being kept (once a cycle ceases and water retention normalizes).

Enanthate and cypionate are the most popular testosterone esters, as they do not need to be injected frequently. However, the downside is, they take a while to kick in and produce results. However, with Sustanon 250 users can experience fast results in the early stages of a cycle, due to the presence of propionate and phenylpropionate esters (yet inject at the same frequency as enanthate/cypionate)

For those who have already cycled other testosterone esters, there should be in theory little difference between swapping those esters for Sustanon 250, in terms of dosage guidelines and stacking options.

Sensitive individuals that are prone to side effects on testosterone are likely to experience the same outcome with sustanon 250.

Sustanon 250 Cycles and Stacks

Testosterone is a versatile hormone, suitable for both bulking and cutting cycles alike; due to its simultaneous anabolic and fat-burning effects.

However, Sustanon 250 is typically used in bulking cycles where maximum muscle gain is the goal. Great results can be achieved from running Sustanon on its own, yet many choose to stack it with other steroids that are also suited for adding mass, such as Anadrol.

Sustanon 250 is effective on its own during cutting cycles, promoting muscle retention and decreasing fat mass.

Many bodybuilders are afraid of losing muscle tissue when cutting, due to the catabolic environment that occurs with a calorie deficit; however, testosterone can alleviate such worries of diminished muscle hypertrophy.

A moderate dose of Sustanon 250 (350mg/week) will successfully preserve lean tissue during a cut, especially when stacked with other compounds that aid fat loss and muscle hardening (such as Anavar or Trenbolone).

Additionally, when using Sustanon for a cutting cycle, the use of an anti-aromatase in low doses can prove particularly useful for preventing water retention and gynecomastia.

For informational purposes, here are some common Sustanon 250 cycles and stacks, utilized by bodybuilders today:

Sustanon 250 Beginner Cycle

beginner sustanon 250 cycle

Note: Large gains in hypertrophy (size) and strength can be experienced on lower dosages among beginners, due to the muscles being particularly receptive to exogenous testosterone. Thus, beginners should avoid utilizing high dosages, allowing more potential for growth in future cycles, where higher dosages may be incorporated.

A PCT should begin 4 weeks following the final dosage, with decanoate’s half-life being 15 days and thus taking considerably longer to exit the body. Such PCT timing can also be applied to the steroid cycles below.

Sustanon 250 Intermediate Cycle

intermediate sustanon 250 cycle

This Sustanon 250 cycle will continue adding mass in users who have already taken a cautious dosed testosterone cycle previously.

However, running higher dosages will also produce more pronounced side effects, which we will detail in the side effects section of this guide (further down).

Sustanon 250 and Anavar Cycle (Cutting)

Anavar is an oral steroid, predominantly used for cutting to enhance fat burning and muscle gains.

Thus, users will burn more subcutaneous fat with this cycle and experience additional lean mass; compared to running Sustanon 250 by itself.

Anavar does not aromatize, thus providing a dry and ripped appearance in users who are already relatively low in body fat.

Anavar is a mild steroid, thus cholesterol, blood pressure and liver enzymes will only rise moderately.

sustanon anavar cycle

Note: Users wanting to avoid water retention or bloat on this cutting cycle can take anastrozole. 0.5mg taken every other day will successfully prevent oestrogen levels from rising.

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Sustanon 250 and Deca Durabolin Cycle

deca durabolin sustanon 250
This is a powerful bulking cycle, yet one of the mildest stacks in terms of side effects.

This cycle may be utilized after running several testosterone cycles; promoting further muscle growth.

sustanon 250 deca cycle

Deca Durabolin has long esters and thus is a slow-acting steroid, hence the lengthy 10-week cycle.

Deca Durabolin is typically injected once per week.

Both testosterone and Deca Durabolin remain FDA-approved steroids in the world of medicine today, showcasing their safety when used under medical supervision and in therapeutic dosages.

Sustanon 250 and Trenbolone Cycle

Sustanon 250 and trenbolone are a potent combination, used for either bulking or cutting purposes.

This duo will cause exceptional muscle gains, whilst simultaneously stimulating rapid fat loss; due to high levels of androgens (causing a direct fat burning effect in adipose tissue).

These two compounds are perhaps the best steroids for increasing lean mass when run simultaneously.

sustanon 250 trenbolone cycle

However, this cycle is only suitable for advanced steroid users due to trenbolone’s toxic nature, in regards to cardiovascular health.

If this cycle is utilized for cutting purposes, an anti-oestrogen such as anastrozole may be used to prevent water retention, however doing so may exacerbate high blood pressure; due to it inhibiting the aromatase enzyme and thus worsening cholesterol ratios.

Sustanon 250 / Anadrol / Trenbolone Cycle

Note: This cycle is only typically performed by experienced steroid users.

This is by far the most potent bulking cycle a bodybuilder can take, causing unrivalled increases in mass.

Even users who have taken steroids for decades are likely to make impressive gains from this cycle, due to the sheer power of this trio.

testosterone anadrol tren cycle

This cycle should only be taken on rare occasions, with it having devastating effects on the heart and liver.

Liver strain will be significant (albeit most likely tolerable), due to Anadrol being the only hepatotoxic compound present.

However, cholesterol levels change drastically, almost certainly causing some level of hypertension. The risk of developing arteriosclerosis and heart disease is high with this cycle, thus if users have a history of such in their family; it may be wise to avoid such an extreme cycle.

Testosterone suppression will almost certainly shut down, requiring the most aggressive PCT possible; ideally a trio of Clomid, Nolvadex and hCG.

Although the above cycles are the most popular protocols, testosterone can also be successfully stacked with other anabolic steroids, such as:

Sustanon 250 Results – Before & After

testosterone cycle before after

This before and after picture demonstrates the typical results in users after their first testosterone/Sustanon 250 cycle.

Testosterone’s fat-burning effects are often underappreciated, with them being arguably as powerful as testosterone’s anabolic properties.

Thus, weight gain may not be the best method for tracking results on testosterone; with before and after pictures being more telling.

Users may lose some weight post-cycle, signifying a decrease in estrogen and thus a loss in extracellular fluid.

However, lean muscle tissue will be retained after a cycle finishes, should users continue lifting weights regularly.

Strength gains of 50+lbs are common (on main compound lifts) when taking testosterone for the first time.

Sustanon 250 Side Effects

As with other testosterone products, Sustanon 250 can produce several undesirable side effects.

Firstly, androgenic-related side effects, including oily skin, acne, accelerated baldness and increased aggressiveness are fairly common.

As with all steroids, tolerance differs from person to person. It is only possible to gauge such sensitivity once a cycle is embarked upon.

That said, if users are particularly prone to acne breakouts or currently suffer from male pattern baldness, testosterone and other androgenic steroids can be expected to worsen such conditions.

Further unwanted side effects can be experienced due to heightened oestrogen levels, that build up during a Sustanon 250 cycle, due to aromatization (the conversion of testosterone into oestrogen).

Heightened oestrogen levels can cause increased water retention and gynecomastia – the formation of breast tissue.

The initial stages of gynecomastia typically involve itchy or sore nipples, developing into a notable mass of tissue behind the nipple. If left unchecked, such tissue can continue to expand and is only rectifiable with surgery.

Thankfully, most users find testosterone tolerable and do not suffer from gynecomastia. For those that do, such oestrogen-related side effects can usually be controlled with either an anti-oestrogen or AI (aromatase inhibitor).

Anti-oestrogen products (such as Nolvadex and Clomid) actively compete with oestrogen at a receptor level, reducing their effects.

Both Nolvadex and Clomid are inexpensive and easy to source – it is always advisable to have an ample supply on hand during and after a cycle. They are also the primary drugs used during post cycle therapy (PCT), to kickstart endogenous testosterone production.

It is also possible to reduce oestrogen levels by taking an anti-aromatase drug, such as Letrozole or Anastrozole. These drugs reduce the conversion of testosterone into oestrogen and are typically taken during a cycle by those prone to oestrogenic side effects.

Testosterone will also suppress endogenous testosterone levels, causing potential testicular atrophy (shrinkage). Thus, at the end of any cycle always ensure to run a proper post cycle therapy aiding the recovery of natural hormone production.

Sustanon 250 does not cause any hepatic (liver) implications due to it being an injectable steroid.

Sustanon 250, and other testosterone esters, will raise LDL cholesterol levels; however, this effect is acute compared to other AAS.

In fact, testosterone appears to be one of the least destructive steroids from a cardiovascular standpoint; however, precautions should still be taken; including fish oil supplementation (4g/day), regular cardio and frequent checkups with your doctor to monitor blood lipids.