Rad 150 vs Rad 140: Which is the Better SARM?

Dr George TouliatosDisclaimer: SARMs are only to be used for research purposes, as they are non-FDA-approved compounds and thus may cause adverse effects. If you have any questions or concerns, Dr. Touliatos is currently available for consultation.


SARMs (selective androgen receptor modulators) are becoming increasingly popular in the bodybuilding world, with them being easy to source thanks to their legal nature (when used for experimental purposes).

SARMs are designed to mitigate the side effects of anabolic steroids via tissue selectivity, which involves specifically targeting the androgen receptors. Thus, its objective is to merely stimulate receptors that promote anabolism rather than ones that will cause side effects.

SARMs ultimately promise the same benefits as anabolic steroids, albeit with less potency. Users can expect increased:

  1. Muscle mass
  2. Muscular strength
  3. Fat loss
  4. Endurance

What is RAD 140?

RAD 140 (Testolone) is the most popular of the SARM family, producing significant gains without excessive side effects. RAD 140 is like the equivalent of testosterone in the anabolic steroid world, with its reward-to-risk ratio being more favourable than other SARMs.

In our experience, RAD 140 users typically gain up to 10 pounds of lean muscle in a single cycle. This may not sound like much, but it can make a dramatic difference visually, especially when users are simultaneously burning fat.

We have also seen users add up to 50 pounds on compound exercises from their first RAD 140 cycle. Thus, it appears that RAD 140’s strength-enhancing properties surpass its anabolic ones.

What is RAD 150?

RAD 150 (TLB-150) is a new esterified version of RAD 140, with a benzoate ester now being formed.

This modification creates higher alkalinity, extending the SARM’s half-life and creating more steady concentrations in the blood.

RAD 140 already has a half-life of 60 hours; thus, an increased half-life means that RAD 150 will stay in a user’s system for even longer and thus may be slightly slower to take effect.

RAD 150 vs RAD 140: Our Results

Our patient’s lab results show that RAD 150 does not present the same toxicity as RAD 140, being approximately 15% less in terms of cholesterol alterations and liver enzymes.

Our SHBG tests indicate endogenous testosterone suppression to be more pronounced with RAD 150, by approximately 20–30%.

Thus, it is more important to run an effective PCT with RAD 150 to recover natural testosterone levels.

This recovery process may take a few weeks longer for RAD 150 due to the HPTA (hypothalamic-pituitary-testicular axis) being more affected.

RAD 150 users under our care also report 10-15% more muscle gains on average, compared to those that use RAD 140. Strength gains are even more pronounced on RAD 150, being closer to a 20% increase.

Disclosure: We do not accept any form of advertising on Inside Bodybuilding. We monetize our practice via doctor consultations and carefully chosen supplement recommendations, which have given our patients excellent results.

Best SARMs Company in 2024

Swiss Chems (Pills)

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Sports Technology Labs (Liquid)

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Sports Technology Labs is our recommended US source for SARMs in liquid and powder form.

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Dose

SARM companies typically have RAD 150 dosed lower than RAD 140 due to its extra potency.

A typical cycle of RAD 150 is dosed at 10 mg/day for 8 weeks.

However, users will typically take RAD 140 at 15 mg/day for 8 weeks.

Cost

RAD 150 works out to be slightly more expensive per bottle.

Here is how their prices compare (source: sportstechnologylabs.com):

  • RAD 140: $64.99 (15 mg/ml) – 30 ml
  • RAD 150: $69.99 (10 mg/ml) – 30 ml

Taste

Anecdotally, we have found that RAD 150 tastes considerably better, which can be attributed to the addition of the new benzoate ester.

What the Research Says

RAD 140 Studies

Anabolism

Research in monkeys demonstrated a 10% increase in mass from a RAD 140 dosage of 0.1 mg/kg per day for 28 days (1). This would translate to 7.5 mg per day for a 75-kg man.

Interestingly, dosages exceeding 0.1 mg/kg did not produce any further increases in mass.

Researchers also found that liver enzymes and prostate mass in the monkeys remained stable.

Another study on rats showed that a RAD 140 dose of 3 mg/kg per day produced the same amount of muscle gains vs. a 1 mg/kg dose of testosterone (2).

This gives us some insight into why a high dose of RAD 140 may rival the muscle-building power of anabolic steroids. However, 3 mg/kg of RAD 140 per day in humans should be considered a megadose, with side effects likely to be severe.

There is also evidence that excessive dosages of RAD 140 can even cause muscle atrophy, as rats at risk of sarcopenia had a higher mortality risk when taking 5 mg per kg/day of RAD 140 (3).

Neuroprotective

Androgens have been shown to demonstrate neuroprotective qualities in research. We have also seen the same cognitive-enhancing effects with RAD 140 in rats (4), giving great promise for the treatment of dementia-related diseases. RAD 140 could eventually be considered a more optimal treatment vs. testosterone for such, as the latter causes prostatic hyperplasia.

RAD 150 Studies

There is a lack of medical research conducted on RAD 150 at this time, so it is very much an experimental SARM, albeit with promising early findings.

FAQ

If RAD 150 is better than RAD 140, why is RAD 140 more popular?

RAD 140’s popularity stems from it simply being around for longer. RAD 150 is a new SARM in comparison, and thus its effects aren’t known by many people.

Is RAD 140 or RAD 150 safe?

There is not enough clinical research to suggest that RAD 140 or RAD 150 are safe. RAD 140 and RAD 150 are only legal for experimental purposes, and thus human consumption is prohibited.

Our experience suggests SARMs like RAD 140 replicate similar anabolic effects to anabolic steroids, but with milder side effects. Thus, there is a case that SARMs are safer than anabolic steroids; however, more data is needed before reaching such a conclusion.

Does RAD 140 or RAD 150 need a PCT?

RAD 140 and RAD 150 are both suppressive SARMs, and thus a PCT should be implemented upon cycle cessation to accelerate endogenous testosterone recovery.

In our experience, SERMs such as Nolvadex and Clomid produce the best results in healing the HPTA (hypothalamic-pituitary-testicular axis).

Without taking a PCT, it can take several weeks for RAD 140 and RAD 150’s testosterone levels to return to normal.

We have found RAD 150 to be more suppressive than RAD 140, potentially requiring a couple of PCT medications for swift recovery.

Do I need to take liver support with RAD 140 or RAD 150?

It is always a good idea to take TUDCA (tauroursodeoxycholic acid) when taking any potential hepatotoxic oral compound. This bile salt supplement will minimize hepatic stress and prevent ALT and AST levels from rising excessively. We have found 500 mg/day to be an effective dose for users taking SARMs.

RAD 150 vs RAD 140, Who Wins?

Rad 140 bottle

Based on our early anecdotal labs, RAD 150 appears to be the better SARM, with an improved reward-to-risk ratio.

However, very little research exists for RAD 150; thus, it remains an unknown substance (even more so than RAD 140).

Co Authors :

(1) https://pubmed.ncbi.nlm.nih.gov/24900290/

(2) https://academic.oup.com/endo/article/154/9/3294/2423518?login=false

(3) https://pubmed.ncbi.nlm.nih.gov/37758180/

(4) https://pubmed.ncbi.nlm.nih.gov/24428527/